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Amoebic vs Crohn's Colitis — RACP Adult Medicine MCQ

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HardInfectious DiseasesAmoebic vs Crohn's ColitisRACP Adult Medicine

A 40-year-old man with post-travel diarrhoea has segmental right-sided colitis with granulomas on biopsy. He was recently in a tropical region. Before diagnosing IBD, what must be excluded?

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Correct answer: E — Amoebic colitis (E. histolytica)

Amoebic colitis mimics Crohn's histologically (granulomas). Must exclude before immunosuppression – starting steroids for misdiagnosed amoebiasis can be fatal.

Reference: eTG – 2025 – Antibiotic; eTG – 2025 – GI