Ibrutinib Platelet Dysfunction — RACP Adult Medicine MCQ

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ModerateHaematologyIbrutinib Platelet DysfunctionRACP Adult Medicine

A 65-year-old man with CLL on ibrutinib has bruising and epistaxis. Platelets normal, INR and APTT normal. Mechanism?

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Correct answer: A — Ibrutinib inhibits BTK-dependent platelet adhesion/aggregation via GPVI pathway

Ibrutinib inhibits BTK in platelets → impaired collagen receptor (GPVI) signalling. Standard coag tests normal. Hold 3–7 days pre-procedure.

Reference: AMH – 2025; eTG – 2025 – Haematology