A 65-year-old man with metastatic CRPC on abiraterone develops fatigue, hypotension. 9 AM cortisol 120 nmol/L. He has been on prednisolone 5 mg BD.

Question

A 65-year-old man with metastatic CRPC on abiraterone develops fatigue, hypotension. 9 AM cortisol 120 nmol/L. He has been on prednisolone 5 mg BD. Most likely cause of adrenal insufficiency?

Accepted Answer

Prednisolone-induced HPA axis suppression

Answer

Primary AI from abiraterone

Answer

Autoimmune

Answer

Pituitary metastasis

Answer

Adrenal metastases

Adrenal Insufficiency Abiraterone — RACP Adult Medicine MCQ

A 65-year-old man with metastatic CRPC on abiraterone develops fatigue, hypotension. 9 AM cortisol 120 nmol/L. He has been on prednisolone 5 mg BD. Most likely cause of adrenal insufficiency?