Safest TKI Vascular Risk — RACP Adult Medicine MCQ

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EasyHaematologySafest TKI Vascular RiskRACP Adult Medicine

A 65-year-old man with CML on nilotinib develops PAD. Which alternative TKI has the lowest vascular risk?

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Correct answer: C — Imatinib

Imatinib has the lowest vascular toxicity of all TKIs. Nilotinib and ponatinib have the highest. Switch to imatinib if significant PAD.

Reference: eTG – 2025 – Haematology; ELN – 2020