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Lamotrigine Pregnancy — RACP Adult Medicine MCQ

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ModerateNeurologyLamotrigine PregnancyRACP Adult Medicine

A 45-year-old man with epilepsy on lamotrigine discovers his partner is 6 weeks pregnant. She has been seizure-free for 3 years. Management of lamotrigine in pregnancy?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Continue with monthly serum level monitoring and dose adjustment

Lamotrigine clearance increases up to 300% in pregnancy. Monthly levels essential with dose increases. Post-delivery, reduce dose within 2–3 weeks.

Reference: AMH – 2025; eTG – 2025 – Neurology