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Sarcoid Hypercalcaemia Rx — RACP Adult Medicine MCQ

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EasyEndocrinology & DiabetesSarcoid Hypercalcaemia RxRACP Adult Medicine

A 55-year-old man with sarcoidosis develops hypercalcaemia (3.2 mmol/L) and AKI. PTH suppressed, 1,25-OH D elevated. After hydration, what definitive treatment?

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Correct answer: DCorticosteroids (prednisolone 20–40 mg daily)

Corticosteroids directly inhibit macrophage 1-alpha-hydroxylase. Response typically within days. Ketoconazole is steroid-sparing alternative.

Reference: eTG – 2025 – Endocrinology