SLE Cryoglobulinaemia — RACP Adult Medicine MCQ

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HardRheumatologySLE CryoglobulinaemiaRACP Adult Medicine

A 42-year-old woman with SLE develops livedo reticularis, digital ischaemia. Cryoglobulins positive (type II), C4 very low, HCV negative. What cause?

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Correct answer: D — SLE-associated secondary cryoglobulinaemia

Type II mixed cryoglobulinaemia in HCV-negative SLE is autoimmune-mediated. Low C4 with normal C3 = classical pathway activation.

Reference: eTG – 2025 – Rheumatology