GBS Axonal Variant — RACP Adult Medicine MCQ

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ModerateNeurologyGBS Axonal VariantRACP Adult Medicine

A 30-year-old man with ascending weakness and areflexia has NCS showing demyelinating pattern. What antibody is associated with the axonal variant (AMAN)?

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Correct answer: D — Anti-GM1 IgG

Anti-GM1 and anti-GD1a IgG associated with AMAN (axonal GBS), often post-Campylobacter. Anti-GQ1b = Miller Fisher variant.

Reference: eTG – 2025 – Neurology; EAN/PNS – 2023