EBV Lymphoma on Immunosuppression — RACP Adult Medicine MCQ

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HardHaematologyEBV Lymphoma on ImmunosuppressionRACP Adult Medicine

A 35-year-old man with IBD on azathioprine and infliximab develops EBV-positive DLBCL. What is the first management step?

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Correct answer: D — Cease azathioprine – may allow immune reconstitution and lymphoma regression

EBV-driven lymphoproliferative disorder on immunosuppression may respond to immunosuppression reduction alone before needing chemotherapy.

Reference: eTG – 2025 – Haematology; ECCO – 2024