TFR Molecular Relapse — RACP Adult Medicine MCQ

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ModerateHaematologyTFR Molecular RelapseRACP Adult Medicine

A 55-year-old woman on CML imatinib for 8 years attempts TFR. What happens in ~50% of patients who attempt TFR?

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Correct answer: C — BCR-ABL1 becomes detectable requiring TKI restart

~50% have molecular relapse on TFR but >95% regain response when TKI is restarted. Monthly molecular monitoring is essential.

Reference: eTG – 2025 – Haematology; ELN – 2020; EURO-SKI