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Antisynthetase ILD Treatment — RACP Adult Medicine MCQ

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ModerateRheumatologyAntisynthetase ILD TreatmentRACP Adult Medicine

A 40-year-old woman with anti-Jo-1 antisynthetase syndrome develops worsening ILD. HRCT shows bilateral GGO with NSIP pattern. What is first-line treatment?

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Correct answer: D — Mycophenolate mofetil plus corticosteroids

Antisynthetase-ILD: corticosteroids + MMF is increasingly preferred first-line. Antifibrotics added for progressive fibrosis.

Reference: eTG – 2025 – Rheumatology; TSANZ – 2023