MASLD Weight Loss — RACP Adult Medicine MCQ

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ModerateGastroenterology & HepatologyMASLD Weight LossRACP Adult Medicine

A 50-year-old man with MASLD has F3 fibrosis on biopsy. What is the single most important intervention for fibrosis regression?

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Correct answer: C — Weight loss ≥10% of body weight

Weight loss ≥10% is associated with fibrosis regression in NASH. GLP-1 RAs facilitate this. Resmetirom is emerging as a specific MASH therapy.

Reference: eTG – 2025 – Gastrointestinal; AASLD – 2023