Deferasirox Nephrotoxicity — RACP Adult Medicine MCQ

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ModerateClinical PharmacologyDeferasirox NephrotoxicityRACP Adult Medicine

A 45-year-old man with beta-thalassaemia major on deferasirox develops worsening renal function (eGFR dropping from 80 to 50). What is the most likely cause?

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Correct answer: C — Deferasirox nephrotoxicity

Deferasirox causes dose-dependent nephrotoxicity in 20–30% of patients. Monthly creatinine monitoring is mandatory. Switch chelator if creatinine rises >33%.

Reference: AMH – 2025; eTG – 2025 – Haematology