Pirfenidone Photosensitivity — RACP Adult Medicine MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: D — Contact dermatitis
Pirfenidone commonly causes photosensitivity (8–12% of patients) through a phototoxic mechanism. Management includes strict sun avoidance, broad-spectrum SPF 50+ sunscreen, protective clothing, and timing outdoor activity to avoid peak UV hours. Dose reduction may be needed during summer months. It does NOT require permanent cessation unless phototoxicity is severe and unmanageable. Patients should be counselled about photosensitivity risk BEFORE starting pirfenidone. The alternative antifibrotic (nintedanib) does not cause photosensitivity but has GI side effects instead.
Reference: AMH – 2025 – Pirfenidone; eTG – 2025 – Respiratory