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Plummer-Vinson Syndrome — RACP Adult Medicine MCQ

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EasyGastroenterology & HepatologyPlummer-Vinson SyndromeRACP Adult Medicine

A 65-year-old woman presents with dysphagia and a sensation of food sticking at the level of the cricoid cartilage. She has iron deficiency anaemia with koilonychia and angular stomatitis. Barium swallow shows a thin web in the post-cricoid region. What is this syndrome?

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Correct answer: C — Plummer-Vinson syndrome (Paterson-Brown-Kelly)

The triad of dysphagia, iron deficiency anaemia, and post-cricoid oesophageal web is Plummer-Vinson syndrome (also called Paterson-Brown-Kelly syndrome in UK/Australia). It predominantly affects middle-aged women. Treatment includes iron replacement (which often leads to web resolution) and endoscopic dilation if the web persists. The syndrome carries a slightly increased risk of post-cricoid squamous cell carcinoma, warranting surveillance.

Reference: eTG – 2025 – Gastrointestinal