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Heerfordt Syndrome — RACP Adult Medicine MCQ

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EasyGeneral Internal MedicineHeerfordt SyndromeRACP Adult Medicine

A 40-year-old man presents with bilateral parotid swelling, uveitis, fever, and a facial nerve palsy. Chest X-ray shows bilateral hilar lymphadenopathy. Serum ACE is elevated. What is this clinical syndrome called?

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Correct answer: D — Heerfordt syndrome (uveoparotid fever)

Heerfordt syndrome is a specific clinical presentation of sarcoidosis characterised by parotid gland enlargement, uveitis, fever, and cranial nerve palsies (most commonly facial nerve – CN VII). It is distinct from Löfgren syndrome (bilateral hilar lymphadenopathy, erythema nodosum, polyarthralgia). Both have a generally favourable prognosis. Treatment with corticosteroids is indicated for the uveitis and facial nerve palsy.

Reference: eTG – 2025 – Respiratory