skip to main content

Marfan Syndrome — RACP Adult Medicine MCQ

Instant feedback + full explanation. One question, done properly.

ModerateCardiologyMarfan SyndromeRACP Adult Medicine

A 40-year-old man with known Marfan syndrome presents for cardiac surveillance. Echocardiography shows an aortic root diameter of 48 mm with mild aortic regurgitation. He is normotensive. What pharmacological therapy is recommended to reduce the rate of aortic root dilation?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Atenolol (or other beta-blocker)

Beta-blockers are the standard pharmacological therapy recommended for Marfan syndrome to reduce the rate of aortic root dilation and the risk of aortic dissection/rupture. ARBs (losartan) may provide additional benefit. Prophylactic aortic root surgery is considered when the diameter reaches ≥50 mm (or ≥45 mm with risk factors such as family history of dissection, rapid growth >3 mm/year, or severe AR).

Reference: eTG – 2025 – Cardiovascular; ESC – 2022 – Aortic Disease Guidelines