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LADA/Type 1 Diabetes — RACP Adult Medicine MCQ

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ModerateEndocrinology & DiabetesLADA/Type 1 DiabetesRACP Adult Medicine

A 35-year-old woman presents with polyuria, polydipsia, and a random blood glucose of 28 mmol/L. Her HbA1c is 10.2% (88 mmol/mol). She has a BMI of 23, and GAD antibodies are positive. Blood ketones are 1.2 mmol/L. What is the most appropriate initial management?

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Correct answer: DBasal-bolus insulin

This patient has latent autoimmune diabetes of adults (LADA) – a form of type 1 diabetes presenting in adulthood. Positive GAD antibodies, normal BMI, and young age support this diagnosis. Insulin therapy is required as beta-cell destruction is the underlying pathology. SGLT2 inhibitors carry a risk of euglycaemic DKA in type 1 diabetes. Metformin and sulfonylureas are inappropriate first-line choices.

Reference: eTG – 2025 – Endocrinology; ADEA/ADS – 2024 – Type 1 Diabetes Management