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COPD Exacerbation — RACP Adult Medicine MCQ

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EasyRespiratoryCOPD ExacerbationRACP Adult Medicine

A 68-year-old man with COPD presents with an acute exacerbation. He has increased dyspnoea, increased sputum volume, and purulent sputum. According to the COPD-X guidelines, which antibiotic is first-line for a moderate exacerbation in the community?

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Correct answer: D — Amoxycillin 500 mg TDS for 5 days

The COPD-X guidelines recommend amoxycillin as first-line antibiotic for acute exacerbations with purulent sputum in the community setting. Doxycycline is an alternative for penicillin-allergic patients. Duration is typically 5 days. Antibiotics are indicated when at least two of the three Anthonisen criteria are met (increased dyspnoea, increased sputum volume, increased sputum purulence).

Reference: Lung Foundation Australia/TSANZ – 2025 – COPD-X Plan V2.78