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Lamotrigine Rash — RACP Paediatrics MCQ

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ModerateNeurology & DevelopmentLamotrigine RashRACP Paediatrics

A 9-year-old with known epilepsy is well controlled on lamotrigine. He develops a widespread morbilliform rash 3 weeks after a dose increase. What should be done?

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Correct answer: A — Stop lamotrigine immediately and seek urgent medical review due to risk of SJS/TEN

Any rash on lamotrigine must be taken seriously. The drug should be stopped immediately due to the risk of SJS/TEN. Risk is higher with rapid dose escalation and concurrent valproate use.

Reference: AMH Children's Dosing Companion – 2024