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PNAC in Prematurity — RACP Paediatrics MCQ

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ModerateNeonatologyPNAC in PrematurityRACP Paediatrics

A premature infant at 30 weeks has conjugated jaundice at 3 weeks. He is on parenteral nutrition. Hepatitis B and metabolic screens are negative. USS shows no biliary dilatation. What is the most likely cause?

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Correct answer: C — Parenteral nutrition-associated cholestasis

PNAC is the most common cause of conjugated jaundice in preterm infants on PN. Strategies: early enteral feeds, lipid minimisation, cycling PN, fish-oil lipid emulsions.

Reference: RCH Melbourne – 2024