Subclinical Hypothyroidism in Down Syndrome — RACP Paediatrics MCQ

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ModerateEndocrinologySubclinical Hypothyroidism in Down SyndromeRACP Paediatrics

A 6-year-old child with Down syndrome is found to have TSH of 12 mU/L and normal fT4. What is this called?

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Correct answer: D — Subclinical hypothyroidism

Subclinical hypothyroidism (elevated TSH with normal fT4) is common in Down syndrome (~30%). Annual thyroid screening is recommended. Treatment with levothyroxine is considered if TSH is persistently >10.

Reference: RCH Melbourne – 2024