Emicizumab Mechanism — RACP Paediatrics MCQ

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HardHaematology & OncologyEmicizumab MechanismRACP Paediatrics

A 10-year-old boy with haemophilia A has been started on emicizumab prophylaxis. How does emicizumab work?

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Correct answer: D — Bispecific antibody that bridges FIXa and FX, mimicking the cofactor function of FVIII

Emicizumab bridges FIXa and FX, bypassing the need for FVIII. Given subcutaneously. Effective in patients with and without inhibitors. Does not interfere with standard coagulation assays.

Reference: RCH Melbourne – 2024