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Risperidone Hyperprolactinaemia — RACP Paediatrics MCQ

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ModerateEndocrinologyRisperidone HyperprolactinaemiaRACP Paediatrics

A 14-year-old girl with irregular periods is found to have a prolactin level of 85 mcg/L (elevated). She is taking risperidone for behavioural difficulties. What is the most likely cause of the elevated prolactin?

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Correct answer: A — Risperidone-induced hyperprolactinaemia

Antipsychotics (especially risperidone) are the most common cause of drug-induced hyperprolactinaemia via D2 receptor blockade. Dose reduction or switch to a prolactin-sparing agent (aripiprazole) may be needed.

Reference: RCH Melbourne – 2024