TAM in Down Syndrome — RACP Paediatrics MCQ

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HardNeonatologyTAM in Down SyndromeRACP Paediatrics

Down syndrome neonate: WCC 80 with circulating blasts at day 2, asymptomatic. Diagnosis?

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Correct answer: E — Transient abnormal myelopoiesis

TAM: ~10% of T21 neonates. Usually resolves 1-3 months but 20% develop AMKL within 1-3 years.

Reference: RCH Melbourne – 2024