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Valproate Teratogenicity Counselling — RACP Paediatrics MCQ

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HardNeurology & DevelopmentValproate Teratogenicity CounsellingRACP Paediatrics

14-year-old on valproate for epilepsy, considering future pregnancy. Counselling?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DHighest teratogenicity risk of all ASMs – avoid in females of childbearing potential

10% malformation rate, 8-10 point IQ reduction. Switch to safer ASM where possible.

Reference: AMH – 2024