Eosinophilic Asthma Biologic — RACP Paediatrics MCQ

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HardRespiratoryEosinophilic Asthma BiologicRACP Paediatrics

Severe asthma with eosinophils 600/mcL despite high-dose ICS/LABA. Best biologic?

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Correct answer: A — Mepolizumab or dupilumab

Elevated eosinophils predict response to anti-IL-5 (mepolizumab) or anti-IL-4Rα (dupilumab).

Reference: National Asthma Council Australia – 2024