Steroid-Induced Osteoporosis — RACP Paediatrics MCQ

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ModerateNephrologySteroid-Induced OsteoporosisRACP Paediatrics

A 6-year-old with nephrotic syndrome has been on prednisolone for 8 weeks. His bone mineral density should be monitored because long-term corticosteroids cause what complication?

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Correct answer: C — Osteoporosis and increased fracture risk

Long-term corticosteroid use causes osteoporosis through decreased osteoblast activity, increased osteoclast activity, reduced calcium absorption, and secondary hyperparathyroidism. Children on frequent or prolonged steroid courses should have bone density monitoring, calcium/vitamin D supplementation, and weight-bearing exercise encouraged.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Steroid Side Effects