skip to main content

Neonatal HIV Prophylaxis — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

ModerateNeonatologyNeonatal HIV ProphylaxisRACP Paediatrics

A term neonate born to an HIV-positive mother on antiretroviral therapy has an undetectable maternal viral load at delivery. What prophylaxis does the neonate require?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Zidovudine (AZT) for 4 weeks

Neonates born to HIV-positive mothers with undetectable viral load and on ART require zidovudine prophylaxis for 4 weeks (low-risk). Higher-risk infants (detectable viral load, no ART, preterm) require combination ART. HIV PCR testing at birth, 6 weeks, and 12 weeks guides management. Breastfeeding advice varies by setting.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: HIV Perinatal Prophylaxis