Cisplatin Monitoring — RACP Paediatrics MCQ

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ModerateHaematology & OncologyCisplatin MonitoringRACP Paediatrics

A 12-year-old undergoing treatment for osteosarcoma receives cisplatin chemotherapy. What specific monitoring is required?

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Correct answer: D — Audiometry (hearing) and renal function (creatinine clearance)

Cisplatin causes ototoxicity (sensorineural hearing loss, especially high-frequency) and nephrotoxicity. Serial audiometry and renal function monitoring (GFR, electrolytes including Mg2+) are mandatory. Adequate hydration and avoidance of concurrent nephrotoxic/ototoxic agents minimise risk.

Reference: ANZCHOG – 2024 – Treatment Guidelines: Osteosarcoma