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CLABSI Management — RACP Paediatrics MCQ

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ModerateHaematology & OncologyCLABSI ManagementRACP Paediatrics

A 6-year-old child with a central venous catheter develops fever, rigors, and positive blood cultures growing coagulase-negative staphylococci. He is on chemotherapy for ALL. What is the first-line antibiotic for this central line-associated bloodstream infection?

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Correct answer: D — IV vancomycin (pending sensitivities)

CLABSI with coagulase-negative staphylococci in oncology patients: IV vancomycin is first-line pending sensitivities (high rates of methicillin resistance in CoNS). Line removal is considered if: failure to clear within 72 hours, fungal CLABSI, tunnel infection, or S. aureus CLABSI.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: CLABSI in Oncology