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Tertiary Hyperparathyroidism — RACP Paediatrics MCQ

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HardNephrologyTertiary HyperparathyroidismRACP Paediatrics

A 14-year-old with ESRD on haemodialysis has secondary hyperparathyroidism with PTH 8 times the upper limit of normal despite phosphate binders and calcitriol. What complication may develop?

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Correct answer: BTertiary hyperparathyroidism (autonomous PTH secretion)

Prolonged stimulation of parathyroid glands in CKD can lead to autonomous PTH secretion (tertiary hyperparathyroidism), where PTH remains elevated even when calcium/phosphate/vitamin D are corrected. Calcimimetics (cinacalcet) or parathyroidectomy may be needed.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: CKD-MBD