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ACEi in Alport — RACP Paediatrics MCQ

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ModerateNephrologyACEi in AlportRACP Paediatrics

An 8-year-old boy with Alport syndrome has progressive proteinuria. What class of medication slows disease progression?

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Correct answer: A — ACE inhibitors or ARBs

ACE inhibitors (or ARBs) are the cornerstone of renoprotective therapy in Alport syndrome, reducing proteinuria and slowing progression to ESRD. Treatment should be commenced at the onset of microalbuminuria. Despite this, most patients with X-linked Alport progress to ESRD by early adulthood.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Alport Syndrome