skip to main content

MPGN vs MCD — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

HardNephrologyMPGN vs MCDRACP Paediatrics

A 3-year-old presents with generalised oedema, proteinuria, and hypoalbuminaemia. His complement levels (C3 and C4) are markedly low. Serum creatinine is rising. Renal biopsy shows membranoproliferative glomerulonephritis (MPGN). What distinguishes this from typical minimal change NS?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Normal complement in MCD vs low complement in MPGN

MPGN presents with nephrotic +/- nephritic features and persistently low complement (C3, sometimes C4). This contrasts with MCD which has normal complement. MPGN has a poorer prognosis than MCD and often does not respond to corticosteroids. C3 glomerulopathy is a subtype with isolated low C3.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Glomerulonephritis