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Vaccination During Steroids — RACP Paediatrics MCQ

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ModerateNephrologyVaccination During SteroidsRACP Paediatrics

A 6-year-old presents with generalised oedema, proteinuria (3+), and hypoalbuminaemia. He is started on prednisolone 60 mg/m2/day. His mother asks about vaccination. What is the advice regarding live vaccines during corticosteroid treatment?

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Correct answer: A — Live vaccines are contraindicated during high-dose corticosteroid treatment (≥2 mg/kg/day for ≥14 days); inactivated vaccines can be given

Live vaccines (MMR, varicella, rotavirus) are contraindicated during and for at least 1 month after cessation of immunosuppressive doses of corticosteroids (≥2 mg/kg/day or ≥20 mg/day prednisolone for ≥14 days). Inactivated vaccines can be given but may have reduced immunogenicity.

Reference: Australian Immunisation Handbook – 2025 – Immunocompromised Patients