LTBI Treatment — RACP Paediatrics MCQ

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ModerateInfectious DiseaseLTBI TreatmentRACP Paediatrics

A 15-year-old is diagnosed with latent TB infection (positive IGRA, normal CXR, asymptomatic). What is the recommended treatment?

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Correct answer: C — Isoniazid for 6-9 months (or rifampicin for 4 months)

LTBI treatment in children reduces the risk of progression to active TB by 60-90%. Standard regimens include isoniazid for 6-9 months or rifampicin for 4 months. Shorter regimens (3 months isoniazid + rifampicin) may also be used. Pyridoxine supplementation prevents isoniazid-induced neuropathy.

Reference: Therapeutic Guidelines – 2024 – Antibiotic: Latent TB