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Cerebral Toxoplasmosis — RACP Paediatrics MCQ

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HardInfectious DiseaseCerebral ToxoplasmosisRACP Paediatrics

A 7-year-old presents with a ring-enhancing lesion in the brain on MRI. He is immunocompromised post-transplant. Toxoplasma serology is positive. What is the empirical treatment?

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Correct answer: A — Pyrimethamine + sulfadiazine + folinic acid

Cerebral toxoplasmosis in immunocompromised patients: pyrimethamine + sulfadiazine (or clindamycin) + folinic acid is the standard treatment. Duration is at least 6 weeks. Secondary prophylaxis is continued until immune reconstitution.

Reference: Therapeutic Guidelines – 2024 – Antibiotic: Toxoplasmosis