Varicella Treatment Immunocompromised — RACP Paediatrics MCQ

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ModerateInfectious DiseaseVaricella Treatment ImmunocompromisedRACP Paediatrics

A 9-year-old on chronic immunosuppression for nephrotic syndrome develops fever and varicella. He has >100 vesicular lesions covering his trunk and limbs with some haemorrhagic lesions. What is the treatment?

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Correct answer: B — IV aciclovir

Varicella in an immunocompromised child requires IV aciclovir (500 mg/m2 TDS or 10 mg/kg TDS) due to the risk of disseminated varicella, varicella pneumonitis, hepatitis, and DIC. Oral therapy is insufficient for immunocompromised patients.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Varicella in Immunocompromised