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Vaccine-Strain Varicella — RACP Paediatrics MCQ

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EasyInfectious DiseaseVaccine-Strain VaricellaRACP Paediatrics

A child develops a widespread vesicular rash 14 days after receiving the MMR-V vaccine. What has occurred?

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Correct answer: C — Vaccine-strain varicella (expected mild reaction)

Vaccine-strain varicella can occur 5-26 days post-MMRV or varicella vaccination, presenting with a mild, sparse vesicular rash. It is generally self-limiting and much milder than wild-type varicella. The rash may be localised or generalised. It is minimally infectious.

Reference: Australian Immunisation Handbook – 2025 – Varicella Vaccine