skip to main content

Infliximab Immunogenic Failure — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

HardGastroenterologyInfliximab Immunogenic FailureRACP Paediatrics

A 10-year-old with Crohn's disease has been in remission on infliximab. His infliximab trough level is 1.2 mcg/mL (target >5 mcg/mL) and anti-infliximab antibodies are present. What does this indicate?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Immunogenic failure (antibody-mediated loss of response)

Low trough levels with detectable anti-drug antibodies indicate immunogenic failure. Options include adding an immunomodulator to reduce antibody formation, or switching to an alternative biologic (e.g. adalimumab or vedolizumab).

Reference: AUSPGHAN – 2024 – Therapeutic Drug Monitoring in IBD