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Medication in ASD — RACP Paediatrics MCQ

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ModerateNeurology & DevelopmentMedication in ASDRACP Paediatrics

A 6-year-old with autism spectrum disorder is showing aggression and self-injurious behaviour that is not responding to behavioural interventions. What is the recommended pharmacological approach?

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Correct answer: D — Start risperidone (low-dose, off-label) with careful monitoring

Risperidone (low-dose) is approved in Australia for behavioural disturbance in autism when behavioural strategies have failed. It reduces irritability, aggression, and self-injury. Monitoring for metabolic side effects (weight gain, dyslipidaemia, hyperglycaemia), prolactin elevation, and extrapyramidal effects is essential.

Reference: RACP – 2024 – Paediatric Curriculum: ASD Management