Pre-Biologic Screening — RACP Paediatrics MCQ

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ModerateGastroenterologyPre-Biologic ScreeningRACP Paediatrics

A 10-year-old with IBD is on infliximab. Prior to starting biologic therapy, what screening tests should have been performed?

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Correct answer: D — TB screening (Mantoux/IGRA), hepatitis B serology, varicella immunity, and live vaccine catch-up

Before starting anti-TNF therapy, patients require screening for latent TB (Mantoux or IGRA), hepatitis B (surface antigen, core antibody, surface antibody), varicella immunity, and completion of all age-appropriate vaccinations (including live vaccines, which are contraindicated during biologic therapy).

Reference: AUSPGHAN – 2024 – Position Statement on Biologic Therapy in Paediatric IBD