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Neonatal Lupus Heart Block — RACP Paediatrics MCQ

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HardCardiologyNeonatal Lupus Heart BlockRACP Paediatrics

A newborn with maternal anti-Ro (SSA) and anti-La (SSB) antibodies is found to have a heart rate of 55 bpm. ECG shows complete AV block with a regular ventricular rate. What is the cause?

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Correct answer: E — Neonatal lupus-associated congenital complete heart block

Congenital complete heart block (CCHB) is associated with transplacental passage of maternal anti-Ro/SSA antibodies (in mothers with SLE or Sjogren syndrome) causing inflammation and fibrosis of the fetal conduction system. Pacemaker insertion is required if symptomatic or if the ventricular rate is <55 bpm.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Congenital Heart Block