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FeNO Interpretation — RACP Paediatrics MCQ

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ModerateRespiratoryFeNO InterpretationRACP Paediatrics

A 14-year-old with poorly controlled asthma is asked to perform a fractional exhaled nitric oxide (FeNO) test. His FeNO is 55 ppb. What does this indicate?

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Correct answer: C — Elevated FeNO suggesting eosinophilic airway inflammation likely responsive to corticosteroids

FeNO ≥35 ppb in children indicates eosinophilic airway inflammation that is likely to respond to ICS. FeNO can guide ICS dose adjustment: high FeNO suggests increasing ICS, low FeNO (<20 ppb) may allow step-down. It is useful for monitoring adherence and phenotyping difficult asthma.

Reference: National Asthma Council Australia – 2024 – Australian Asthma Handbook