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Metformin Toxicity — RACP Paediatrics MCQ

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ModerateEmergency PaediatricsMetformin ToxicityRACP Paediatrics

A 5-year-old child accidentally ingests his grandmother's metformin tablets. He is asymptomatic 2 hours post-ingestion. What metabolic complication should be monitored for?

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Correct answer: E — Lactic acidosis

Metformin toxicity can cause lactic acidosis, which may be delayed in onset. Children who ingest metformin should be observed for at least 12 hours with serial blood gas and lactate monitoring. Haemodialysis may be required for severe toxicity with metabolic acidosis.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Poisoning