Reactive Arthritis — RACP Paediatrics MCQ

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ModerateRheumatologyReactive ArthritisRACP Paediatrics

A 12-year-old presents with a 2-week history of bloody diarrhoea. Stool culture grows Campylobacter jejuni. He develops reactive arthritis 2 weeks later. What HLA type is associated with reactive arthritis?

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Correct answer: A — HLA-B27

Reactive arthritis (formerly Reiter syndrome) occurs 1-4 weeks after GI or GU infection (Campylobacter, Salmonella, Shigella, Yersinia, Chlamydia). HLA-B27 is present in 60-80% of cases. It presents with asymmetric oligoarthritis, often affecting the lower limbs. NSAIDs are the first-line treatment.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Reactive Arthritis