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AML Diagnosis — RACP Paediatrics MCQ

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ModerateHaematology & OncologyAML DiagnosisRACP Paediatrics

A 3-year-old presents with bone pain, fever, and hepatosplenomegaly. FBC shows Hb 72, WCC 3.5, platelets 35. Blood film shows blasts with Auer rods. What is the diagnosis?

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Correct answer: CAcute myeloid leukaemia (AML)

Auer rods (crystallised granules forming rod-shaped inclusions in blast cells) are pathognomonic of AML. AML accounts for approximately 15-20% of childhood leukaemia. Treatment involves intensive chemotherapy. Outcomes are inferior to ALL but have improved with risk-stratified therapy and supportive care.

Reference: ANZCHOG – 2024 – Treatment Guidelines: AML