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Hodgkin Lymphoma Diagnosis — RACP Paediatrics MCQ

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ModerateHaematology & OncologyHodgkin Lymphoma DiagnosisRACP Paediatrics

A 14-year-old boy presents with a painless, firm mass in the left supraclavicular fossa. CT shows a mediastinal mass with multiple enlarged lymph nodes. Biopsy shows Reed-Sternberg cells in a background of lymphocytes and histiocytes. What is the diagnosis?

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Correct answer: A — Hodgkin lymphoma (classical type)

Classical Hodgkin lymphoma: painless lymphadenopathy (often cervical/supraclavicular) with mediastinal involvement. Reed-Sternberg cells (large binucleated cells with prominent nucleoli) are pathognomonic. Staging is by PET-CT. Treatment is risk-adapted chemotherapy +/- radiotherapy with excellent cure rates (>90%).

Reference: ANZCHOG – 2024 – Treatment Guidelines: Hodgkin Lymphoma