Steroid-Sparing in NS — RACP Paediatrics MCQ

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HardNephrologySteroid-Sparing in NSRACP Paediatrics

A 5-year-old boy with steroid-sensitive nephrotic syndrome has had 3 relapses in 6 months despite correct prednisolone dosing. What steroid-sparing agent is commonly used first-line?

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Correct answer: E — Levamisole

Levamisole is commonly used as a first-line steroid-sparing agent for frequently relapsing or steroid-dependent nephrotic syndrome in children. It has immunomodulatory properties and is well-tolerated. Other options include cyclophosphamide, mycophenolate, calcineurin inhibitors, and rituximab for refractory cases.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Nephrotic Syndrome