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Congenital Syphilis — RACP Paediatrics MCQ

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HardInfectious DiseaseCongenital SyphilisRACP Paediatrics

A newborn presents at 2 weeks with snuffles (nasal discharge), hepatosplenomegaly, a desquamating rash, and a positive RPR/VDRL. Mother's syphilis status was unknown during pregnancy. What is the treatment?

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Correct answer: D — IV benzylpenicillin for 10-14 days

Congenital syphilis: IV benzylpenicillin (or IM procaine penicillin) for 10-14 days. All neonates born to mothers with syphilis (treated or untreated) require assessment. Treponema pallidum is the causative organism. Long-term follow-up including ophthalmological and audiological assessment is essential.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Congenital Syphilis